that's a pretty serious load of misfires
i'd start by troubleshoting your ignition system. you may be due for new plugs, wires, and/or coil pack. wouldn't hurt to check the condition of the fuel injectors while you're at it.
to test the coil pack, you can measure the resistance of each coil with an ohm-meter to make sure they're within spec (whatever the specs are, i don't know offhand, you'd have to look them up somewhere). make sure the injectors are clean, and you can measure the resistance on them to make sure they're within spec as well. wouldn't hurt to run a compression check too.
that covers the basics. make sure you have compression, fuel, and spark.
hope that helps at least somewhat.